CPI helps make great ideas and inventions a reality. We’re a team of intelligent people using advances in science and technology to solve the biggest global challenges in healthcare and sustainability.
Through our incredible people and innovation infrastructure, we collaborate with our partners in industry, academia, government, and the investment community to accelerate the development and commercialisation of innovative products.
From health technologies and pharmaceuticals to sustainable food and materials innovations, we turn the entrepreneurial spirit and radical thinking of our people and partners into incredible impact that makes our world a better place.
We are seeking a motivated Scientist 2 – Proteomics to join our dynamic analytical team. within the national biologics manufacturing centre in Darlington to support the Next-Generation Cancer Diagnostics programme (NG-Dx). NG-Dx is a strategic initiative led by CPI in the UK, aimed at accelerating the development and adoption of advanced, multi-omics-based technologies for early cancer detection.
This role is ideal for someone with foundational proteomics knowledge who is keen to develop hands‑on expertise in LC‑MS/MS workflows and support high‑impact programs across discovery and development. You will work in a multidisciplinary environment alongside protein scientists, bioinformaticians, and process development teams to deliver high‑quality mass spectrometry data that informs decision‑making.
Key responsibilities
Proteomics & mass spectrometry
Perform sample preparation for LC‑MS/MS analyses, including lysis, protein digestion, desalting, and peptide cleanup.
Support operation of mass spectrometers (e.g. Orbitrap, Q‑TOF) and nano‑LC systems.
Conduct routine instrument QC, calibration, and basic troubleshooting.
Assist in developing and optimising proteomic and peptide mapping workflows for biologics characterisation.
Data processing & interpretation
Data processing using software such as Proteome Discoverer, and DIA-NN.
Perform peptide/protein identification and quantification.
Contribute to clear and concise data summaries for internal reports, cross‑functional project meetings and to external stakeholders.
Cross‑functional collaboration
Collaborate across teams to deliver project milestones and continuous improvement
Participate in experimental planning and optimisation discussions.
Providing mentoring and training to junior team members
Uphold excellent documentation practices in electronic laboratory notebooks (ELNs) and follow company data integrity standards.
Operational support
Contribute to lab maintenance, reagent management, and compliance with safety procedures.
Support implementation of new technologies, automation tools, and workflow improvements.
Supporting business development through technical input and client engagement
The successful candidate will be educated to a minimum of HNC/Foundation Degree level (or equivalent) in a Scientific/Engineering discipline with industrial experience and:
Be experienced in LC-MS/MS workflows for Proteomics applications, to include routine instrument maintenance, tuning, calibration, and troubleshooting for both nano-LC systems and high-resolution mass spectrometers.
Hands‑on experience with DDA, DIA, and targeted quantification workflows
Have experience in using proteomics data analysis software such as Proteome Discoverer, and DIA-NN.
Ability to interpret MS/MS spectra and validate peptide/protein identifications
Have an understanding of Data Integrity principles.
Be able to demonstrate the ability to work independently and collaboratively across multidisciplinary teams.
Be an effective communicator with experience in data presentation and documentation.
It would be great if you had one or more of the following:
Experience with phosphoproteomics, glycoproteomics, or other PTM‑focused workflows.
Membership of a relevant professional body.
Experience mentoring or training others.
Familiarity with statistical analysis tools for data analysis and visualisation.
Familiarity with high-throughput screening using automated liquid handling systems.
Please note this is a 12-month fixed-term role.
At CPI, we offer a wide range of benefits to our employees, this includes:
Up to 36 days holiday, including bank holidays – Plus a holiday purchasing scheme
Generous pension scheme
Life assurance and accident insurance schemes
Flexible working
Learning and Development Opportunities
Free parking
Find out more about our culture and benefits.